I only invest in things I follow closely. I have over 100K growing in the 401K, so I let that just do it's thing and don't worry about it. There is a lot of opportunity in 3D printing but again - I don't follow it closely enough to invest in it.
I do have a few bitcoin and litecoin but that is really just a moonshot thing to see what happens. I intend to hold these for a very long time.
My uncle swing trades triple leverage EFTs and I guess he has an algorithm where he hasn't lost a trade yet. He says it takes some serious balls and he has come close to losing his ass a few times, but he has always ended up coming out a head or even. I may start doing this and following his algorithm.
Right now... my focus is on the really big win. I'm building companies now. That is the best way to make big bucks.