You think an offense has never caught a defense unprepared with a play? How many times have you seen a read-option pass to the weak side with a one receiver route?
You think there is some magical defensive alignment and scheme that allows both attack and is solid from sideline to sideline with no weakness against ANY play call?
A magical defense that never lets an opponent get into free space and catch a ball? A defense that doesn't have, even hidden, an exposed pressure point?
The problem with your litany of complaints is that it ranges from the mundane to the exotic. Run defense in nickel and dime is a problem. Preparing for every unknown read option wrinkle is not.