I've adjusted my fly many times before.
The key is "maximizing the talent of the players." If you have players with a certain skill set, you put them in positions to use those skills, and try to keep them out of situations that ask them to do things they don't do well, just because it's your "system." That was apparent in the two Minny games - was it last year? - where in the first one, Joe Barely didn't match up Alexander with Jefferson, and Jefferson went wild. Second game, Barely did match Alexander up, and Jefferson was much quieter.