Not sure how wide you mean by your wide, but yes it changes things.
Its dependent on alignment (and I still haven't reviewed the game) but if that player is attacking the LOS and with no coverage responsibilities (unless zone blitz) then yes, he is behaving like a lineman. The stance might be an issue, but its less of an issue wide.
Remember the argument against the 2-4 nickel and dime is that its vulnerable to the run in the middle due to size. Replacing Matthews and Perry with Neal and Peppers is a size increase that offsets the lost size of a NT. Each guy wist wanted to put on the field in his 3-3 nickel was a 280-285 pound guy so that you could have beef and a little pass rush.