All-time series is tied 6-6-1, with the Packers winning the last 3. Last time the 2 teams met, October 2 2011, Packers clobbered the Broncos 49-23. Aaron Rodgers threw for 408 yards and 4 TD's. Kyle Orton was the Broncos starting QB.
This year defensively, Broncos are 2nd in points allowed per game and 1st yards allowed. They are 4th in INT's with 9, 1st in forced fumbles with 11, and 1st in sacks with 26. Packers are #1 in points allowed despite being only 15th in yards allowed. Part of this is because they have given up a lot of rushing yards to opposing QB's, which shouldn't be a problem against Manning. Packers are #3 in sacks with 23.
Offensively Packers are 10th in YPG while Broncos are 29th. Packers are 5th in PPG and Broncos are 13th, so both teams have been more efficient at scoring than moving the ball. One huge difference is that Manning leads the NFL with 10 INT's while Rodgers has just 2. Rodgers and Manning have faced each other once when Manning was with Indy with the Packers winning 34-14 as Manning was intercepted twice. Denver has had trouble running the ball all year, with just 519 rushing yards and a 3.6 YPC. Packers have been up and down with 764 rushing yards and a 4.5 YPC.
I see a fairly low scoring game with both teams being challenged to protect their QB.
Packers 23
Broncos 20