If the starting O-line is missing all four tackles who were on the 53 man roster that started the season, and the next best alternative after those four, the offense will be severely compromised, especially if the starting LG is the #4 guard.

If the starting corners plus another from the original 53 are on the sidelines, the defense will suffer.

If the most versatile DB around whom the defense was conceived is not playing, much is lost.

When two or three of the above are combined in a single game, winning would be difficult even with Rodgers.