It could be, but that might mean hanging your entire offensive offensive prep on Jared Cook and Mitchell Henry. Healthy receivers will help regardless.
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Seems like you're writing off Richard Rodgers. I actually like the chances of Backman more than Mitchell Henry.
It might have to do with a lot of subpackages, and McCarthy often talks about matchups and exploiting them.
If you go back to the 2010 SB run, Aikman/Buck talk a few times about how the DCs have trouble keeping up with all the substitutions made from one play to the next.
https://www.youtube.com/watch?v=Gb4zVkCkuNE