I am leery of using a first round pick on an offensive tackle, as some have suggested the Packers do. It's a what-if, but -and it could happen - what if Sherrod and Bulaga come back healthy for camp? If you take an o-tackle in round one, you've got two young starters - Newhouse and Bulaga - plus a very solid back up in Barclay, plus Sherrod, plus another first rounder? That seems like too many high-round picks - 3 - at one position.
I'm also slightly leery of spending your first rounder on a safety, unless you're sure that 1) McMillan is not the answer, and, 2) that the guy you're picking is physically head and shoulders above any safety you've got now.
I trust TT and BPA, but in terms of matching need to BPA I'd prefer a defensive lineman or an inside linebacker, or maybe (only maybe) a running back, if MM promises to actually use him.