Tirzepatide

[call_me_ishmael]

Dunno if any of you husky fellas are on this shit, but holy fuck does this shit ever work. I strongly recommend it to you all and think it is easily worth the cost. Shit is the bomb and in 20 years everyone will micro dose whatever the modern off-patent equivalent is then. You feel so damn good you just know it's helping you live longer.

[Fosco33]

Not for me. But I have a friend who’s in the peptide business.

If you’ve been around the block with weight loss stuff, you’ve probably seen a few waves of “miracle” drugs come and go. Back in the day there was fen-phen, which worked but ended up causing serious heart valve problems and got pulled. Then you had things like sibutramine (Meridia), which helped some people lose weight but ended up raising heart attack and stroke risk. Orlistat is still around but a lot of folks couldn’t stick with it because of the GI side effects. More recently, phentermine is still prescribed, but it’s usually short-term and carries risks if someone has blood pressure or heart issues.

That’s part of why drugs like tirzepatide get so much buzz now. They’re based on hormones your body already makes, so they tend to feel a little more “natural” compared to the old stimulants or fat blockers. The results are stronger too way more people are losing 15 to 20 percent of their body weight compared to maybe 5 to 10 percent with the older options. But at the same time, we don’t have decades of data yet. The rodent thyroid tumor risk, the lean muscle loss questions, and what happens after ten or twenty years of use are still unknowns.

Diet and exercise, boring as it sounds, never really go out of style. The benefits carry across everything better fitness, strength, sleep, blood pressure, mood. You won’t lose 20 percent of your weight in a year with lifestyle alone unless you’re on a very structured plan, but you also don’t have to worry about stopping a drug and regaining half the weight.

So I’d say tirzepatide looks like the strongest medication we’ve had so far, especially compared to the old ones that ended up with major safety problems. But it’s still a tool, not a cure. The folks who do best are the ones who combine it with the basics — moving more, eating better, and treating the medication like a support rather than the whole solution.

[call_me_ishmael]

Consider giving a microdose a try. It is a wild treatment. People quit drinking, smoking, etc on it. It just overall reduces your desire for bad shit and makes you want to be productive but not a robot either like many other drugs. LLY is developing a new similar drug to get people off of SSRIs and ADHD meds.

I went on Vyvanse for a few months to try it out and all I ever did was work. My wife told me it was awful because I would do a 10 hour day, do kids for a few hours, then go back and do 3-4 more hours and that's pretty much all I did. Just grind none-stop and made that the focus on my life.

I actually think I focus better on tirzepatide without the obsession aspects. It's pretty wild.

The biggest thing though is it makes you make healthy choices. I eat insanely clean and exercise 5 nights per week now.

It's a pretty wild thing.

[Fosco33]

Sounds like speed or coke. lol

I’m just fine being 20lb overweight and not taking drugs. All my labs are always good - so idk.

[texaspackerbacker]

One of the very rare times that I agree with Fosco. I never heard of this stuff until I Googled it after seeing it mentioned here. Fat pigs who resort to diabetes drugs when they don't have diabetes deserve whatever eventual side effects come along.

[MadtownPacker]

Man up and lay off the soda, candy, chips and especially bread! Do pushups, calisthenics, run or just walk. People bragging about all the weight loss they didn’t earn is lame. No will power and bunch of excuses why. If you can physically move you can do it.

[MadtownPacker]

One of the very rare times that I agree with Fosco. I never heard of this stuff until I Googled it after seeing it mentioned here. Fat pigs who resort to diabetes drugs when they don't have diabetes deserve whatever eventual side effects come along.

Props to you. You always say you eat whatever you want but you also always speak of tennis and other activity.

[call_me_ishmael]

Man up and lay off the soda, candy, chips and especially bread! Do pushups, calisthenics, run or just walk. People bragging about all the weight loss they didn’t earn is lame. No will power and bunch of excuses why. If you can physically move you can do it.

I don't see it that way. Most people on these drugs work out a lot. At least I do. They really help get your mind right to be able to workout and eat healthy. I 100% believe that I put in the work to lose a shit load of weight. The drug helps no doubt, but the drug isn't busting ass lifting with high intensity or chugging protein shake after protein shake.

[texaspackerbacker]

Props to you. You always say you eat whatever you want but you also always speak of tennis and other activity.

Yeah, there's no need to sacrifice on eating what you want, which in my case IS plenty of soda, candy, chips, ice cream, etc. First of all, most of that nutritional crap is just that, crap anyway. Secondly, it's quantity that makes fat people fat. Oh yeah, genetics has a little bit to do with it too, but mostly it's as simple as eating too much. Exercising because it's FUN of course is a good thing - competition and all (not to mention that "other activity" you spoke of hahaha). I wouldn't recommend doing boring stuff, though. If somehow you like doing weights or jogging or pushups or whatever, then fine, go for it. But if you don't like it/it isn't fun, then the hell with it.

Being happy is the biggest key to being healthy. For the record, I'm not the perfect model of fitness either - maybe 15 or 20 pounds overweight. But that in itself isn't gonna shorten my life or lessen my happiness.

The meds? As I said, I hadn't even heard of this Tirzepatide, but I have heard of Ozempic and others that apparently are similar - developed for real medical conditions, but they happen to take away the desire to eat. That to me is kinda a shame in itself, cutting into the joy of eating. Undoubtedly taking that kind of thing will catch up to them in the end somehow that hasn't yet been discovered - and maybe it should.

[MadtownPacker]

I don't see it that way. Most people on these drugs work out a lot. At least I do. They really help get your mind right to be able to workout and eat healthy. I 100% believe that I put in the work to lose a shit load of weight. The drug helps no doubt, but the drug isn't busting ass lifting with high intensity or chugging protein shake after protein shake.

Protein shake after shake huh? Why? Gets your mind right to workout huh? Sounds like a willpower thing. Very interesting.

P I remember you being a huskie boy and now that you’re married and a father, I know it’s a lot harder to keep up on yourself with all of life’s duties. I know I put on weight when the kids were small. Now that I live alone and a single guy I have time to focus on my own shit. Don’t think I don’t understand. I just don’t like the idea of taking artificial shit if I don’t have to.

Unless I’m tripping muscle is more dense than fat. In other words, you can look thinner with muscle and weigh the same as when you’re bigger looking with fat. That why I prefer the body weight stuff. Have found that I’m just as strong and many times stronger than the buff or geared up gym bros. Too much focus on certain muscle. Try to be strong from all angles and have entire body strength.

[bobblehead]

Ish, I would have sworn I commented on this thread, but alas nothing from me. I know I did somewhere, maybe the investing thread or FYI where you mentioned tirz. You said something like everyone would be on it soon enough and I told you it was the tip of the iceberg. So, here goes. I'm not claiming that I managed to get some Reta from a former championship bodybuilder as that would be illegal, but if I had, oh my is it the shit. Its tirz with a mechanism to stop the "stall" in weightloss. It attacks visceral fat (the stuff that is internal and presses on your organs). It reduces inflammation which helps the joints. Basically its the absolute shit. Should be sold legally prescription by end of the year or early next year. But when the grey market beats them to the public you know its good.

I see Foscoe mentioned peptides which is the new rage (for good reason). There are a couple peptides that you can add in that are well documented and definitely change the game for us mid 50 guys. I plan on not for real, but theoretically acquiring some soon. And as foscoe said, you can't replace exercise and diet, but I'd argue that some of us struggle with the fork and knife so the assist makes it all come together. And no, its not just willpower. There are metabolic reasons some people are born hungry and just CAN NOT eat simple carbs because of the domino effect it causes. Same as some people eat for shit, are 200 pounds overweight and don't get diabetes but my mother in law is 5'2" 105lbs, active and eats right but got type 2 at age 35.

[call_me_ishmael]

It's not illegal since it's not a controller substance.

Tirz is awesome and the Reta numbers are just insane. Just make sure you're getting plenty of sleep because the HRV changes w/ reta supposedly make it hard to get enough deep sleep and truly recover from the day. I haven't taken Reta so I can't personally speak to it but the results online are insane.

Titrate slowly and you will lose way more than the clinical trials number suggest IMO. I stayed on 5mg of tirz for a year and just went to 7.5 and have lost 75ish. I am no longer fat by any objective measure but def want to keep losing until I get lean. I've never been lean so that will be a nice change.

I go back and forth as to whether Reta is priced in to the stock because it's a game changer for sure. I have a bunch in my freezer just haven't touched it yet since I get Lily Tirz for 30 bucks a month and it is just easier/less risky that way. I know I'm getting good stuff when it's from a pharmacy. When I do go grey, I do group buys when the batches are tested so I at least some confidence in what I'm getting.

I also take grey ghk-cu and that also seems to work well. My skin def looks better. I have been trying to avoid loose skin and so far it seems to be working-ish.